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Dement Geriatr Cogn Disord. 2014;37(5-6):294-306. doi: 10.1159/000355478. Epub 2013 Dec 31.

Self-reported head injury and risk of late-life impairment and AD pathology in an AD center cohort.

Author information

1
University of Kentucky Alzheimer's Disease Center, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Ky., USA.

Abstract

AIMS:

To evaluate the relationship between self-reported head injury and cognitive impairment, dementia, mortality, and Alzheimer's disease (AD)-type pathological changes.

METHODS:

Clinical and neuropathological data from participants enrolled in a longitudinal study of aging and cognition (n = 649) were analyzed to assess the chronic effects of self-reported head injury.

RESULTS:

The effect of self-reported head injury on the clinical state depended on the age at assessment: for a 1-year increase in age, the OR for the transition to clinical mild cognitive impairment (MCI) at the next visit for participants with a history of head injury was 1.21 and 1.34 for the transition from MCI to dementia. Without respect to age, head injury increased the odds of mortality (OR = 1.54). Moreover, it increased the odds of a pathological diagnosis of AD for men (OR = 1.47) but not women (OR = 1.18). Men with a head injury had higher mean amyloid plaque counts in the neocortex and entorhinal cortex than men without.

CONCLUSIONS:

Self-reported head injury is associated with earlier onset, increased risk of cognitive impairment and dementia, increased risk of mortality, and AD-type pathological changes.

PMID:
24401791
PMCID:
PMC4057973
DOI:
10.1159/000355478
[Indexed for MEDLINE]
Free PMC Article

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