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Rev Argent Microbiol. 2013 Oct-Dec;45(4):262-6. doi: 10.1016/S0325-7541(13)70034-8.

Macrolide resistance in Streptococcus pneumoniae isolated from Argentinian pediatric patients suffering from acute otitis media.

Author information

  • 1Servicio de Microbiología, Hospital de Pediatría "Prof. Dr. J. P. Garrahan", Buenos Aires, Argentina.
  • 2Servicio Antimicrobianos, Instituto Nacional de Enfermedades Infecciosas, ANLIS "Dr. Carlos G. Malbrán", Buenos Aires, Argentina.
  • 3Servicio de Otorrinolaringología, Hospital de Pediatría "Prof. Dr. J. P. Garrahan", Buenos Aires, Argentina.
  • 4Servicio de Microbiología, Hospital de Pediatría "Prof. Dr. J. P. Garrahan", Buenos Aires, Argentina. Electronic address: hlopar25@gmail.com.

Abstract

Macrolide-resistant Streptococcus pneumoniae emerged in Argentina in 1995, representing 26% of invasive infection isolates in children under 5 years old. The objectives of this study were to describe the prevalence of ermB and mefA genes in macrolide-resistant S. pneumoniae isolates from acute otitis media (AOM) and to determine their genetic relatedness. Between May 2009 and August 2010, 126 S. pneumoniae isolates from 324 otherwise healthy children with a first episode of AOM were included. Twenty six of these isolates (20.6%) were resistant to erythromycin. Most frequent serotypes were: 14 (46.2%), 6A (23.1%), 19F (7.7%) and 9V (7.7%). Twenty (76.9%) carried the mefA gene, 5 (19.2%) have the ermB gene, and 1 (3.9%) both ermB + mefA. Ten clonal types were identified, mostly related to Sweden(15A)-25/ST782 (SLV63), CloneB(6A)/ST473 and England(14)-9/ ST9. This is the first study assessing the mechanisms of macrolide resistance in pneumococci isolates from pediatric AOM in Argentina and their genetic relatedness.

KEYWORDS:

Acute otitis media; Macrolide resistance; Otitis media aguda; Resistencia a macrólidos; Streptococcus pneumoniae

PMID:
24401781
DOI:
10.1016/S0325-7541(13)70034-8
[PubMed - indexed for MEDLINE]
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