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Parasitology. 2014 Jan;141(1):50-65. doi: 10.1017/S0031182013001571.

Novel inhibitors of the Plasmodium falciparum electron transport chain.

Author information

1
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.
2
Department of Chemistry, University of Liverpool, P.O. Box 147, Liverpool, L69 3BX, UK.

Abstract

Due to an increased need for new antimalarial chemotherapies that show potency against Plasmodium falciparum, researchers are targeting new processes within the parasite in an effort to circumvent or delay the onset of drug resistance. One such promising area for antimalarial drug development has been the parasite mitochondrial electron transport chain (ETC). Efforts have been focused on targeting key processes along the parasite ETC specifically the dihydroorotate dehydrogenase (DHOD) enzyme, the cytochrome bc 1 enzyme and the NADH type II oxidoreductase (PfNDH2) pathway. This review summarizes the most recent efforts in antimalarial drug development reported in the literature and describes the evolution of these compounds.

PMID:
24401337
DOI:
10.1017/S0031182013001571
[Indexed for MEDLINE]

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