Format

Send to

Choose Destination
See comment in PubMed Commons below
Mult Scler. 2014 Aug;20(9):1217-23. doi: 10.1177/1352458513518259. Epub 2014 Jan 7.

Disability weight for each level of the Expanded Disability Status Scale in multiple sclerosis.

Author information

1
Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine, South Korea.
2
Department of Neurology, Research Institute and Hospital of National Cancer Center, South Korea nrhks@paik.ac.kr hojinkim@ncc.re.kr.
3
Department of Neurology, Research Institute and Hospital of National Cancer Center, South Korea.
4
Department of Neurology, Samsung Medical Center, South Korea.
5
Department of Neurology, Dongguk University Ilsan Hospital, South Korea.
6
Department of Neurology, Chung-Ang University College of Medicine, South Korea.
7
Department of Neurology, Yeungnam University College of Medicine, South Korea.
8
Department of Neurology, St. Vincent's Hospital, The Catholic University of Korea, South Korea.
9
Department of Neurology, Korea University College of Medicine, South Korea.
10
Department of Neurology, The Catholic University of Korea, South Korea.

Abstract

BACKGROUND:

The Expanded Disability Status Scale (EDSS) is the most widely employed ordinal disability scale in multiple sclerosis (MS). However, how far apart the individual EDSS levels are along the disability spectrum has not been formally quantified.

OBJECTIVES:

The objective of this paper is to generate refined disability weights (DWs) for each of the ordinal EDSS levels.

METHODS:

We performed the person trade-off (PTO) procedure to derive DWs of five representative EDSS categories (2, 4, 6, 7 and 9), and DWs of the remaining EDSS categories were assigned by linear interpolation. The modified Delphi process was used to achieve consensus among raters.

RESULTS:

DWs were 0.021 for EDSS 2, 0.199 for EDSS 4, 0.313 for EDSS 6, 0.617 for EDSS 7, and 0.926 for EDSS 9. Panel members achieved a high degree of consensus for each DW, as indicated by low coefficients of variation.

CONCLUSIONS:

Our DWs confirmed that EDSS is an ordinal scale with highly variable intervals. The availability of DW for each EDSS level allows direct comparison of each MS outcome state with other health states and provides a foundation for the estimation of the disability-adjusted life-years lost of individual patients.

KEYWORDS:

Expanded Disability Status Scale; Multiple sclerosis; disability weight

PMID:
24399825
DOI:
10.1177/1352458513518259
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center