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Glycoconj J. 2014 Apr;31(3):193-7. doi: 10.1007/s10719-013-9516-4. Epub 2014 Jan 8.

GM3 and diabetes.

Author information

1
Division of Glycopathology, Institute of Molecular Biomembranes and Glycobiology, Tohoku Pharmaceutical University, 4-4-1, komatsushima, Aoba-ku, Sendai, 981-8558, Miyagi, Japan, jin@tohoku-pharm.ac.jp.

Abstract

We demonstrated the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and GM3 ganglioside in adipocytes and propose a working hypothesis "metabolic disorders, such as type 2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides". It is expected that the development of novel diagnosis of metabolic syndrome by identifying the specific ganglioside species and a therapeutic strategy "membrane microdomain ortho-signaling therapy".

PMID:
24399479
DOI:
10.1007/s10719-013-9516-4
[Indexed for MEDLINE]

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