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Fish Shellfish Immunol. 2014 Feb;36(2):459-66. doi: 10.1016/j.fsi.2013.12.020. Epub 2014 Jan 4.

Studies of macrophage cellular response to the extracellular hydrogen peroxide by tilapia model.

Author information

1
Institute of Fisheries Science, National Taiwan University, Taipei 10617, Taiwan.
2
Department of Aquaculture, National Taiwan Ocean University, Keelung 20248, Taiwan.
3
Freshwater Aquaculture Research Center, Fisheries Research Institute, Council of Agriculture, Changhua 50562, Taiwan.
4
Department of Life Science, National Taiwan University, Taipei 10617, Taiwan.
5
Institute of Fisheries Science, National Taiwan University, Taipei 10617, Taiwan; Department of Life Science, National Taiwan University, Taipei 10617, Taiwan. Electronic address: snchen@ntu.edu.tw.

Abstract

Reactive oxygen species (ROS) may act as signaling molecules in the physiology responses and the present study aims to investigate the effect of extracellular hydrogen peroxide on macrophages cellular response. The results obtained in the present study showed that the extracellular hydrogen peroxide affectively alter the membrane potential of the cell membrane and ion exchange channels in the cell membrane through intracellular NAD turnover that may lead to an intracellular calcium ion concentration alteration and subsequently induce the downstream signal activation.

KEYWORDS:

Cellular physiology; Hydrogen peroxide; Inflammation; Macrophage

PMID:
24398263
DOI:
10.1016/j.fsi.2013.12.020
[Indexed for MEDLINE]
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