Abstract
On the basis of betulinic and oleanolic acids triterpenoids with different with different amine fragments: (3-aminopropoxy)-, 3-acetyl-(3-aminopropyl)amino-, 6-[bis(3-aminopropyl)amino]hexylamino-, (3-aminopropyl)-4-aminosulfonyl-4-phenylamino- at positions C3 and C28 were synthesized. It is shown that betulonic acid amide with 4,4'-diaminodiphenylsulfonic substituent don't render antitumor effect in mice with transplantable Lewis lung carcinoma, but possess significant anti-inflammatory activity.
MeSH terms
-
Animals
-
Anti-Inflammatory Agents / administration & dosage
-
Anti-Inflammatory Agents / chemical synthesis
-
Anti-Inflammatory Agents / chemistry
-
Antineoplastic Agents / administration & dosage
-
Antineoplastic Agents / chemical synthesis
-
Antineoplastic Agents / chemistry
-
Betulinic Acid
-
Carcinoma, Lewis Lung / drug therapy
-
Carcinoma, Lewis Lung / pathology
-
Histamine / toxicity
-
Humans
-
Inflammation / chemically induced
-
Inflammation / drug therapy
-
Mice
-
Oleanolic Acid / administration & dosage*
-
Oleanolic Acid / chemical synthesis*
-
Oleanolic Acid / chemistry
-
Pentacyclic Triterpenes
-
Triterpenes / chemical synthesis*
-
Triterpenes / chemistry
Substances
-
Anti-Inflammatory Agents
-
Antineoplastic Agents
-
Pentacyclic Triterpenes
-
Triterpenes
-
oleanonic acid
-
Oleanolic Acid
-
Histamine
-
Betulinic Acid