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Theranostics. 2013 Dec 7;3(12):986-1003. doi: 10.7150/thno.4827.

Multifunctional iron oxide nanoparticles for diagnostics, therapy and macromolecule delivery.

Author information

1
1. Institute of Materials Research and Engineering (IMRE), ASTAR (Agency for Science, Technology and Research), 3 Research Link, Singapore 117602.
2
2. The Lee Kong Chian School of Medicine, Nanyang Technological University, 50 Nanyang Drive, Research Techno Plaza, Level 4, X-Frontier Block, Singapore 637553.
3
1. Institute of Materials Research and Engineering (IMRE), ASTAR (Agency for Science, Technology and Research), 3 Research Link, Singapore 117602 ; 3. National University of Singapore, Division of Biomedical Engineering, Faculty of Engineering, 7 Engineering Drive 1 Singapore 117576.

Abstract

In recent years, multifunctional nanoparticles (NPs) consisting of either metal (e.g. Au), or magnetic NP (e.g. iron oxide) with other fluorescent components such as quantum dots (QDs) or organic dyes have been emerging as versatile candidate systems for cancer diagnosis, therapy, and macromolecule delivery such as micro ribonucleic acid (microRNA). This review intends to highlight the recent advances in the synthesis and application of multifunctional NPs (mainly iron oxide) in theranostics, an area used to combine therapeutics and diagnostics. The recent applications of NPs in miRNA delivery are also reviewed.

KEYWORDS:

MRI; contrast agents; gold; iron oxide; miRNA delivery; nanoparticles; optical imaging; theranostics.

PMID:
24396508
PMCID:
PMC3881099
DOI:
10.7150/thno.4827
[Indexed for MEDLINE]
Free PMC Article

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