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Genetics. 2014 Jan;196(1):31-63. doi: 10.1534/genetics.112.145144.

Chromosome segregation in budding yeast: sister chromatid cohesion and related mechanisms.

Author information

1
The Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom.

Abstract

Studies on budding yeast have exposed the highly conserved mechanisms by which duplicated chromosomes are evenly distributed to daughter cells at the metaphase-anaphase transition. The establishment of proteinaceous bridges between sister chromatids, a function provided by a ring-shaped complex known as cohesin, is central to accurate segregation. It is the destruction of this cohesin that triggers the segregation of chromosomes following their proper attachment to microtubules. Since it is irreversible, this process must be tightly controlled and driven to completion. Furthermore, during meiosis, modifications must be put in place to allow the segregation of maternal and paternal chromosomes in the first division for gamete formation. Here, I review the pioneering work from budding yeast that has led to a molecular understanding of the establishment and destruction of cohesion.

KEYWORDS:

Chromosome; Cohesin; Keyords placeholder; Meiosis; Mitosis; Segregation

PMID:
24395824
PMCID:
PMC3872193
DOI:
10.1534/genetics.112.145144
[Indexed for MEDLINE]
Free PMC Article

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