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Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1138-43. doi: 10.1073/pnas.1321990111. Epub 2014 Jan 6.

SAD kinases control the maturation of nerve terminals in the mammalian peripheral and central nervous systems.

Author information

1
Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138.

Abstract

Axons develop in a series of steps, beginning with specification, outgrowth, and arborization, and terminating with formation and maturation of presynaptic specializations. We found previously that the SAD-A and SAD-B kinases are required for axon specification and arborization in subsets of mouse neurons. Here, we show that following these steps, SAD kinases become localized to synaptic sites and are required within presynaptic cells for structural and functional maturation of synapses in both peripheral and central nervous systems. Deleting SADs from sensory neurons can perturb either axonal arborization or nerve terminal maturation, depending on the stage of deletion. Thus, a single pair of kinases plays multiple, sequential roles in axonal differentiation.

KEYWORDS:

Calyx of Held; Ia synapse; neuromuscular junction; spinal cord; sympathetic ganglion

PMID:
24395778
PMCID:
PMC3903204
DOI:
10.1073/pnas.1321990111
[Indexed for MEDLINE]
Free PMC Article
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