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Neurosci Lett. 2014 Feb 21;561:86-90. doi: 10.1016/j.neulet.2013.12.051. Epub 2014 Jan 3.

BDNF G196A (Val66Met) polymorphism associated with cognitive impairment in Parkinson's disease.

Author information

  • 1Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstańców Wlkp 72, 70-111 Szczecin, Poland. Electronic address: monika-bialecka@post.pl.
  • 2Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstańców Wlkp 72, 70-111 Szczecin, Poland. Electronic address: mkurz@pum.edu.pl.
  • 3Department of Neurological-Psychiatric Nursing, Medical University of Gdańsk, Al. Jana Pawła II 50, 80-462, Poland; Department of Neurology, St. Adalbert Hospital, Al. Jana Pawła II 50, 80-462 Gdańsk, Poland. Electronic address: annaroszmann@gmail.com.
  • 4Department of Neurological-Psychiatric Nursing, Medical University of Gdańsk, Al. Jana Pawła II 50, 80-462, Poland; Department of Neurology, St. Adalbert Hospital, Al. Jana Pawła II 50, 80-462 Gdańsk, Poland. Electronic address: piotr.amg@wp.pl.
  • 5Department of Neurological-Psychiatric Nursing, Medical University of Gdańsk, Al. Jana Pawła II 50, 80-462, Poland; Department of Neurology, St. Adalbert Hospital, Al. Jana Pawła II 50, 80-462 Gdańsk, Poland. Electronic address: emsitek@gmail.com.
  • 6Clinic of Neurology, Pomeranian Medical University, Unii Lubelskiej 1, 71-251 Szczecin, Poland. Electronic address: khonczar@pum.edu.pl.
  • 7Clinic of Psychiatry, Pomeranian Medical University, Broniewskiego 26, 71-460 Szczecin, Poland. Electronic address: monika.mak@gmail.com.
  • 8Department of Neurology, Marie Curie Regional Hospital, Arkońska 4, 71-455 Szczecin, Poland. Electronic address: jaroszki@interia.pl.
  • 9Clinic of Neurology, Pomeranian Medical University, Unii Lubelskiej 1, 71-251 Szczecin, Poland. Electronic address: monikagj@op.pl.
  • 10Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstańców Wlkp 72, 70-111 Szczecin, Poland. Electronic address: drozdzik@pum.edu.pl.
  • 11Department of Neurological-Psychiatric Nursing, Medical University of Gdańsk, Al. Jana Pawła II 50, 80-462, Poland; Department of Neurology, St. Adalbert Hospital, Al. Jana Pawła II 50, 80-462 Gdańsk, Poland. Electronic address: jaroslawek@gumed.edu.pl.

Abstract

Brain-derived neurotrophic factor (BDNF) is a neurotrophin widely expressed in the mammalian brain, regulating neuronal survival and known to influence dopaminergic neurons and cognitive processes. The present study investigated the BDNF Val66Met polymorphism associations with PD risk, and cognitive impairment in PD. A total of 486 study subjects (244 PD and 242 age and sex matched controls) were included in the study. UPDRS score, Hoehn-Yahr staging and the Schwab-England scale were used to assess motor abilities and activity during daily life. The patients were classified into groups with dementia (PDD, n=69) and without it (nPDD, n=166) on the basis of neuropsychological assessment. The most common functional polymorphism in BDNF Val66Met (rs6265, G196A) gene was determined using TaqMan real-time PCR assay. Frequencies of evaluated BDNF alleles and genotypes were similar in PD and the controls. The mean age of disease onset among BDNF Met/Met carriers was later (65.00±6.13) in comparison to Val/Val (57.45±10.68) and Val/Met (56.33±10.91) subjects (p=0.077). The studied BDNF polymorphism was not associated with cognitive status in PD patients. However, patients with Met/Met alleles demonstrated better delayed recall of information than patients with Val/Val alleles. The results of multivariate logistic regression analysis revealed age (p=0.0003) and the disease stage (p=0.002) as independent risk factors predisposing to PD dementia.

KEYWORDS:

BDNF; Dementia; Genetic polymorphism; Parkinson's disease

PMID:
24394906
DOI:
10.1016/j.neulet.2013.12.051
[PubMed - indexed for MEDLINE]
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