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Gynecol Obstet Fertil. 2014 Apr;42(4):269-72. doi: 10.1016/j.gyobfe.2013.08.017. Epub 2014 Jan 3.

[Spontaneous regression of breast cancer after biopsy. About two cases].

[Article in French]

Author information

1
Centre Léon-Bérard, département de chirurgie oncologique, université de Lyon 1, 28, rue Laennec, 69008 Lyon, France.
2
Centre Léon-Bérard, département d'anatomopathologie, université de Lyon 1, 28, rue Laennec, 69008 Lyon, France.
3
Centre Léon-Bérard, département d'oncologie médicale, université de Lyon 1, 28, rue Laennec, 69008 Lyon, France.
4
Université de Lyon, 69000 Lyon, France; Université Lyon-1, ISPB, Lyon, 69622, 69000 Lyon, France; Inserm U1052, centre de recherche en cancérologie de Lyon, 69000 Lyon, France; CNRS UMR5286, centre de recherche en cancérologie de Lyon, 69000 Lyon, France; Centre Léon Bérard, plateforme d'innovation en immunomonitoring et immunothérapie, 69008 Lyon, France.
5
Centre Léon-Bérard, département de chirurgie oncologique, université de Lyon 1, 28, rue Laennec, 69008 Lyon, France. Electronic address: frederic.beurrier@lyon.unicancer.fr.

Abstract

We report two cases of spontaneous regression of breast cancer occurred in our institution. It was about a 34- and an 82-year-old patient. The examination revealed a palpable nodule. In both cases, biopsy revealed a negative immunohistochemical staining for estrogen and progesterone receptors, and HER-2 negative. Histological analysis of the surgical specimen found fibrous tissue rearrangement without carcinoma. In the first case, a sarcoidosis was diagnosed at the same time, the mediastinal nodes mimicked a metastatic cancer. These cases illustrate a rare phenomenon. The main hypothesis is a carcinoma- directed immune response triggered by the biopsy.

KEYWORDS:

Breast cancer; Cancer du sein; Régression spontanée; Sarcoidosis; Sarcoïdose; Spontaneous regression

PMID:
24394327
DOI:
10.1016/j.gyobfe.2013.08.017
[Indexed for MEDLINE]

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