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Nat Rev Endocrinol. 2014 Mar;10(3):129-30. doi: 10.1038/nrendo.2013.261. Epub 2014 Jan 7.

Diabetes: Targeting endoplasmic reticulum to combat juvenile diabetes.

Author information

1
Department of Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8127, St Louis, MO 63110, USA.

Abstract

Limited options for clinical management of patients with juvenile-onset diabetes mellitus call for a novel therapeutic paradigm. Two innovative studies support endoplasmic reticulum as an emerging target for combating both autoimmune and heritable forms of this disease.

PMID:
24393784
PMCID:
PMC4049517
DOI:
10.1038/nrendo.2013.261
[Indexed for MEDLINE]
Free PMC Article

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