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J Org Chem. 2014 Feb 7;79(3):1437-43. doi: 10.1021/jo402170n. Epub 2014 Jan 15.

Copper immobilized on nanosilica triazine dendrimer (Cu(II)-TD@nSiO2)-catalyzed regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles and bis- and tris-triazoles via a one-pot multicomponent click reaction.

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  • 1Department of Chemistry, Catalysis Division, University of Isfahan , Isfahan 81746-73441, Iran.


An efficient, atom-economical, and regioselective synthesis of a wide range of 1,4-disubstituted 1,2,3-triazoles in excellent yields has been achieved via a one-pot three-component reaction of alkynes and sodium azide with organic halides or α-bromo ketones catalyzed by Cu(II)-TD@nSiO2/sodium ascorbate at room temperature. This catalytic system also showed excellent activity in the synthesis of bis- and tris-1,4-substituted 1,2,3-triazoles. Moreover, the catalyst could be recycled and reused for seven cycles without any loss in its catalytic activity.

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