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J Pak Med Assoc. 2013 Nov;63(11):1427-9.

Job's syndrome with an atypical presentation.

Author information

1
Department of Hepatogastroenterology, Aga Khan Hospital for Woman, Karimabad. draayt@yahoo.com
2
Department of Diagnostics and Immunology, Aga Khan Hospital for Woman, Karimabad.
3
Department of Hepatogastroenterology, Aga Khan Hospital for Woman, Karimabad.

Abstract

Hyper Immunoglobulin E syndrome also called Job's or Buckley Syndrome is a rare primary immunodeficiency disease characterized by elevated serum IgE levels (> 2000 IU/ml), recurrent infections and eosinophilia. Other features include coarse facies and non-immunologic abnormalities of the dentition, bones, vasculature and connective tissues. We are reporting a case of a twenty four years old male with coarse facies who presented with severe pallor and upper gastrointestinal bleeding. Investigations revealed markedly elevated serum IgE levels (11,800 IU/ml), severe anaemia, esophageoduodenal erosions, Helicobacter pylori (H. pylori) gastritis and oro-esophageal candidiasis.

PMID:
24392534
[Indexed for MEDLINE]
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