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Front Cell Infect Microbiol. 2013 Dec 19;3:103. doi: 10.3389/fcimb.2013.00103. eCollection 2013.

Drosophila at the intersection of infection, inflammation, and cancer.

Author information

1
Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai New York, NY, USA.

Abstract

Recent studies show that both cellular and humoral aspects of innate immunity play important roles during tumor progression. These interactions have traditionally been explored in vertebrate model systems. In recent years, Drosophila has emerged as a genetically tractable model system for studying key aspects of tumorigenesis including proliferation, invasion, and metastasis. The absence of adaptive immunity in Drosophila provides a unique opportunity to study the interactions between innate immune system and cancer in different genetic contexts. In this review, I discuss recent advances made by using Drosophila models of cancer to study the role of innate immune pathways Toll/Imd, JNK, and JAK-STAT, microbial infection and inflammation during tumor progression.

KEYWORDS:

Drosophila; cancer; infection; inflammation; innate immune response

PMID:
24392358
PMCID:
PMC3867678
DOI:
10.3389/fcimb.2013.00103
[Indexed for MEDLINE]
Free PMC Article

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