Format

Send to

Choose Destination
See comment in PubMed Commons below
PLoS One. 2014 Jan 2;9(1):e84918. doi: 10.1371/journal.pone.0084918. eCollection 2014.

Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults.

Author information

1
Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
2
Department of Clinical Pharmacology, School of Medicine, Flinders University, Adelaide, Australia.
3
Level 3 Hunter Medical Research Institute, School of Medicine & Public Health, University of Newcastle, Newcastle, NSW, Australia.
4
Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, NSW, Australia.

Abstract

BACKGROUND:

Despite the increasing interest towards the biological role of L-ergothioneine, little is known about the serum concentrations of this unusual aminothiol in older adults. We addressed this issue in a representative sample of community-dwelling middle-aged and older adults.

METHODS:

Body mass index, estimated glomerular filtration rate, serum concentrations of L-ergothioneine, taurine, homocysteine, cysteine, glutathione, cysteinylglycine, and glutamylcysteine were evaluated in 439 subjects (age 55-85 years) randomly selected from the Hunter Community Study.

RESULTS:

Median L-ergothioneine concentration in the entire cohort was 1.01 IQR 0.78-1.33 µmol/L. Concentrations were not affected by gender (P = 0.41) or by presence of chronic medical conditions (P = 0.15). By considering only healthy subjects, we defined a reference interval for L-ergothioneine serum concentrations from 0.36 (90% CI 0.31-0.44) to 3.08 (90% CI 2.45-3.76) µmol/L. Using stepwise multiple linear regression analysis L-ergothioneine was negatively correlated with age (rpartial = -0.15; P = 0.0018) and with glutamylcysteine concentrations (rpartial = -0.13; P = 0.0063).

CONCLUSIONS:

A thorough analysis of serum L-ergothioneine concentrations was performed in a large group of community-dwelling middle-aged and older adults. Reference intervals were established. Age and glutamylcysteine were independently negatively associated with L-ergothioneine serum concentration.

PMID:
24392160
PMCID:
PMC3879362
DOI:
10.1371/journal.pone.0084918
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Support Center