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PLoS One. 2013 Dec 31;8(12):e83287. doi: 10.1371/journal.pone.0083287. eCollection 2013.

Cerebral hemodynamics and systemic endothelial function are already impaired in well-controlled type 2 diabetic patients, with short-term disease.

Author information

1
Department of Neurology, Campus Bio-Medico University, Rome, Italy ; Department of Neurology, S. Giovanni Calibita Fatebenefratelli Hospital, Rome, Italy.
2
Department of Neurology, Campus Bio-Medico University, Rome, Italy.
3
Endocrinology, Diabetes and Metabolism, S. Giovanni Calibita Fatebenefratelli Hospital, University of Rome Tor Vergata, Rome, Italy.
4
Department of Neurology, S. Giovanni Calibita Fatebenefratelli Hospital, Rome, Italy.
5
SeSMIT, Service for Medical Statistics & IT, Fatebenefratelli Association for Research, Isola Tiberina, Rome, Italy.

Abstract

OBJECTIVE:

Impaired cerebral vasomotor reactivity (VMR) and flow-mediated dilation (FMD) were found in selected subgroups of type 2 diabetes mellitus (T2DM) patients with long-term disease. Our study aimed to evaluate cerebral hemodynamics, systemic endothelial function and sympatho-vagal balance in a selected population of well-controlled T2DM patients with short-term disease and without cardiac autonomic neuropathy (CAN).

RESEARCH DESIGN AND METHODS:

Twenty-six T2DM patients with short-term (4.40±4.80 years) and well-controlled (HbA1C = 6.71±1.29%) disease, without any complications, treated with diet and/or metformin, were consecutively recruited. Eighteen controls, comparable by sex and age, were enrolled also.

RESULTS:

FMD and shear rate FMD were found to be reduced in T2DM subjects with short-term disease (8.5% SD 3.5 and 2.5 SD 1.3, respectively) compared to controls (15.4% SD 4.1 and 3.5 SD 1.4; p<.001 and p<.05). T2DM patients also displayed reduced VMR values than controls (39.4% SD 12.4 vs 51.7%, SD 15.5; p<.05). Sympatho-vagal balance was not different in T2DM patients compared to healthy subjects. FMD and shear rate FMD did not correlate with VMR in T2DM patients or in controls (p>.05).

CONCLUSIONS:

In well-controlled T2DM patients with short-term disease cerebral hemodynamics and systemic endothelial function are altered while autonomic balance appeared to be preserved.

PMID:
24391751
PMCID:
PMC3877017
DOI:
10.1371/journal.pone.0083287
[Indexed for MEDLINE]
Free PMC Article
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