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Front Neurol. 2013 Dec 20;4:207. doi: 10.3389/fneur.2013.00207. eCollection 2013.

Brain Perfusion Impairment in Neurologically Asymptomatic Adult Patients with Sickle-Cell Disease Shown by Voxel-Based Analysis of SPECT Images.

Author information

1
Department of Neurology, University of Campinas , Campinas , Brazil.
2
Division of Neurology, Department of Neurosciences, Medical University of South Carolina , Charleston, SC , USA.
3
Department of Neurology, University of Campinas , Campinas , Brazil ; Department of Orthodontics, City University of São Paulo , São Paulo , Brazil.
4
Hematology and Hemotherapy Center, University of Campinas , Campinas , Brazil.
5
Division of Nuclear Medicine, Department of Radiology, University of Campinas , Campinas , Brazil.
6
Department of Orthodontics, City University of São Paulo , São Paulo , Brazil.

Abstract

Cerebrovascular lesions are frequently observed in patients with sickle-cell disease (SCD) and these structural lesions are preceded by insidious perfusion deficits. Our aim was to investigate the presence of brain perfusion deficits in neurologically asymptomatic SCD patients, especially affecting microvessels. For this study, 42 SCD patients [33 sickle-cell anemia (HbSS), 6 sickle hemoglobin C disease (HbSC), and 3 sickle β-thalassemia disease (HbSβ)] with mean hematocrit of 25.1 (±4.85; 15.6-38.5) underwent brain perfusion single photon emission computerized tomography (SPECT) using the tracer (99m)Tc-ECD. Images from SCD patients were compared to images of a healthy control group (29 females and 20 males, mean age 31 ± 8; range 25-49 years). Images underwent voxel-wise comparison of regional tracer uptake using paired t-test to estimate the probability of each voxel to have an increased or decreased tracer uptake. When compared to controls, SCD patients exhibited significantly reduced tracer uptake in basal ganglia and thalami, the anterior frontal region and the watershed region of the temporo-parietal-occipital transition (p < 0.05). Our study showed that neurologically asymptomatic adult SCD patients exhibit a pattern of reduced (99m)Tc-ECD tracer uptake demonstrated by SPECT. Early diagnosis of this cerebral vasculopathy has prognostic implications and can be determinant in considering therapeutic alternatives to avoid increasing brain lesion load and progressive disability.

KEYWORDS:

SPECT; brain perfusion; sickle-cell disease; voxel-based analysis

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