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J Orthop Res. 2014 Apr;32(4):606-12. doi: 10.1002/jor.22574. Epub 2014 Jan 6.

In vivo monitoring of implant osseointegration in a rabbit model using acoustic sound analysis.

Author information

1
Department of Orthopedics, University Medicine Rostock, Doberaner Strasse 142, D-18057, Rostock, Germany.

Abstract

Implant osseointegration can currently only be assessed reliably post mortem. A novel method that relies on the principle of acoustic sound analysis was developed to enable examination of the longitudinal progress of osseointegration. The method is based on a magnetic sphere inside a hollow cylinder of the implant. By excitation using an external magnetic field, collision of the sphere inside the implant produces a sound signal. Custom-made titanium implants equipped thusly were inserted in each lateral femoral epicondyle of 20 New Zealand White Rabbits. Two groups were investigated: Uncoated, machined surface versus antiadhesive surface; and calcium phosphate-coated surface versus antiadhesive surface. The sound analysis was performed postoperatively and weekly. After 4 weeks, the animals were euthanized, and the axial pull-out strengths of the implants were determined. A significant increase in the central frequency was observed for the loose implants (mean pull-out strength 21.1 ± 16.9 N), up to 6.4 kHz over 4 weeks. In comparison, the central frequency of the osseointegrated implants (105.2 ± 25.3 N) dropped to its initial value. The presented method shows potential for monitoring the osseointegration of different implant surfaces and could considerably reduce the number of animals needed for experiments.

KEYWORDS:

acoustic testing; animal experiment; implant coating; osseointegration; vibration analysis

PMID:
24391086
DOI:
10.1002/jor.22574
[Indexed for MEDLINE]
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