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Sci Rep. 2014 Jan 6;4:3570. doi: 10.1038/srep03570.

Fluorescence detecting of paraquat using host-guest chemistry with cucurbit[8]uril.

Author information

1
1] State Key Laboratory of Fine Chemicals, Dalian University of Technology, E 224 West Campus, No. 2, Linggonglu, 116024, Dalian, China [2].
2
1] School of Chemistry, Dalian University of Technology, No. 2, Linggonglu, 116024, Dalian, China [2].
3
State Key Laboratory of Fine Chemicals, Dalian University of Technology, E 224 West Campus, No. 2, Linggonglu, 116024, Dalian, China.

Abstract

Paraquat (PQ) is one of the most widely used herbicides in the world, which has a good occupational safety record when used properly. While, it presents high mortality index after intentional exposure. Accidental deaths and suicides from PQ ingestion are relatively common in developing countries with an estimated 300,000 deaths occurring in the Asia-Pacific region alone each year, and there are no specific antidotes. Good predictors of outcome and prognosis may be plasma and urine testing within the first 24 h of intoxication. A fluorescence enhancement of approximately 30 times was seen following addition of PQ to a solution of the supramolecular compound 2MB@CB[8], which comprised two methylene blue (MB) molecules within one cucurbit[8]uril (CB[8]) host molecule. The fluorescence intensity was linearly proportional to the amount of PQ added over the concentration range 2.4 × 10(-10) M-2.5 × 10(-4) M. The reaction also occurred in living cells and within live mice.

PMID:
24389647
PMCID:
PMC3880963
DOI:
10.1038/srep03570
[Indexed for MEDLINE]
Free PMC Article
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