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Bone. 2014 Apr;61:33-8. doi: 10.1016/j.bone.2013.12.022. Epub 2014 Jan 3.

Vertebral bone marrow glucose uptake is inversely associated with bone marrow fat in diabetic and healthy pigs: [(18)F]FDG-PET and MRI study.

Author information

1
Turku PET Centre, University of Turku, PO Box 52, FI-20521 Turku, Finland; Department of Radiology, University of Turku, Medical Imaging Centre of Southwest Finland and Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland.
2
Turku PET Centre, University of Turku, PO Box 52, FI-20521 Turku, Finland.
3
Turku PET Centre, University of Turku, PO Box 52, FI-20521 Turku, Finland; Department of Endocrinology, Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland.
4
Department of Surgery, Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland.
5
Food Chemistry and Food Development, Department of Biochemistry, University of Turku, 20014 Turku, Finland.
6
Department of Radiology, Tampere University and Tampere University Hospital, PL 2000, 33521 Tampere, Finland; Department of Radiology, University of Turku, Medical Imaging Centre of Southwest Finland and Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland. Electronic address: riitta.parkkola@pshp.fi.

Abstract

OBJECTIVES:

Diabetes induces osteoporosis and during osteoporosis, vertebral bone marrow (VBM) adipose tissue amount increases. The association between this adiposity and bone marrow metabolism is unclear. Here, we compared VBM glucose metabolism and fat content in healthy and diabetic pigs, in vivo, using positron emission tomography (PET), in-phase and out-of-phase magnetic resonance imaging and magnetic resonance proton spectroscopy ((1)H MR spectroscopy).

MATERIALS/METHODS:

Eleven pigs (n=11) were used. The intervention group had five diabetic and the control group had six healthy pigs. To measure metabolism, PET-imaging with [(18)F]fluoro-deoxy-glucose ([(18)F]FDG) intravenous tracer was used. 1.5-T MRI with (1)H spectroscopy, in-phase and out-of-phase imaging and chemical TAG analysis of the VBM were performed.

RESULTS:

We found a significant inverse correlation between VBM glucose uptake (GU) and VBM fat content (R=-0.800, p<0.01) and TAG concentration assay (R=-0.846, p<0.05). There was a trend, although non-significant, of a linear correlation between VBM (1)H MR spectroscopy and TAG concentration (R=0.661) and (1)H MR spectroscopy and in-phase and out-of-phase MR imaging (R=0.635).

CONCLUSIONS:

VBM glucose metabolism coupled with VBM fat content may impact diabetic induced osteoporosis.

KEYWORDS:

Bone marrow; Diabetes; Metabolism; Osteoporosis; Spectroscopy

PMID:
24389418
DOI:
10.1016/j.bone.2013.12.022
[Indexed for MEDLINE]

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