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Int Immunopharmacol. 2014 Feb;18(2):365-72. doi: 10.1016/j.intimp.2013.12.018. Epub 2014 Jan 3.

Equine adipose-derived stem cell (ASC) expresses BAFF and its receptors, which may be associated with the differentiation process of ASC towards adipocyte.

Author information

1
Jiangsu Key Laboratory for Molecular & Medical Biotechnology, Life Science College, Nanjing Normal University, Nanjing 210023, PR China; Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, PR China; Jiangsu Key Laboratory for Aquatic Crustacean Diseases, Life Science College, Nanjing Normal University, Nanjing 210023, PR China; Jiangsu Key Laboratory for Supramolecular Medicinal Materials & Applications, Life Science College, Nanjing Normal University, Nanjing 210023, PR China.
2
Jiangsu Key Laboratory for Molecular & Medical Biotechnology, Life Science College, Nanjing Normal University, Nanjing 210023, PR China; Jiangsu Key Laboratory for Aquatic Crustacean Diseases, Life Science College, Nanjing Normal University, Nanjing 210023, PR China; Jiangsu Key Laboratory for Supramolecular Medicinal Materials & Applications, Life Science College, Nanjing Normal University, Nanjing 210023, PR China.
3
Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, PR China.
4
Jiangsu Key Laboratory for Molecular & Medical Biotechnology, Life Science College, Nanjing Normal University, Nanjing 210023, PR China; Jiangsu Key Laboratory for Aquatic Crustacean Diseases, Life Science College, Nanjing Normal University, Nanjing 210023, PR China; Jiangsu Key Laboratory for Supramolecular Medicinal Materials & Applications, Life Science College, Nanjing Normal University, Nanjing 210023, PR China. Electronic address: shuangquan_z@yahoo.com.

Abstract

B cell activating factor (BAFF) and its receptors were regarded as elements of the immune system, regulating the fate of B cell. In recent years, these molecules were identified in a number of normal and pathological tissues, expanding their potential functions beyond the immune system. In this study, on the basis of molecular clone and prokaryotic expression of equine BAFF, we reported that equine adipose-derived stem cell (ASC) expressed BAFF and its receptors, which exhibited the increased expression during ASC adipogenic differentiation in vitro. Moreover, with the addition of recombinant protein His6-sBAFF, an increased differentiation of equine ASC towards adipocyte was detected. These results suggested that BAFF and its receptors might be associated with the differentiation process of ASC towards adipocyte in horse.

KEYWORDS:

Adipogenic differentiation; Adipose-derived stem cell; BAFF; Equine; Horse

PMID:
24389381
DOI:
10.1016/j.intimp.2013.12.018
[Indexed for MEDLINE]

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