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Front Biosci (Landmark Ed). 2014 Jan 1;19:707-17.

Atopic eczema: a disease modulated by gene and environment.

Author information

1
Department of Dermatology, Shanghai Seventh People's Hospital, Shanghai, China;
2
Shanghai University of Traditional Chinese Medicine, Shanghai, China.
3
Department of Dermatology, Shanghai Seventh People's Hospital, 358 Datong Road, Pudong New Area, Shanghai 200137, China.

Abstract

Atopic eczema (AE) is a chronic inflammatory skin disease that is mainly characterized by pruritus and epidermal barrier dysfunction. Between 15% and 20% of children and 1%-3% of adults are affected worldwide. AE is a complex disease triggered by multiple triggers, including gene and environmental factors. Impaired skin barrier function, modifications of the immune system, and hyper-reactivity to environmental stimulation directly cause and aggravate AE. In this review, we provide an overview of the recent developments and future directions in the pathogenesis of AE.

PMID:
24389214
[Indexed for MEDLINE]
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