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Front Biosci (Elite Ed). 2014 Jan 1;6:159-74.

Acquired prosopagnosia: structural basis and processing impairments.

Author information

1
Department of Medicine (Neurology), and Department of Ophthalmology and Visual Sciences, University of British Columbia, Canada.

Abstract

Cognitive models propose a hierarchy of parallel processing stages in face perception, and functional neuroimaging shows a network of regions involved in face processing. Reflecting this, acquired prosopagnosia is not a single entity but a family of disorders with different anatomic lesions and different functional deficits. One classic distinction is between an apperceptive variant, in which there is impaired perception of facial structure, and an associative/amnestic variant, in which perception is relatively intact, with subsequent problems matching perception to facial memories, because of either disconnection or loss of those memories. These disorders also have to be distinguished from people-specific amnesia, a multimodal impairment, and prosop-anomia, in which familiarity with faces is preserved but access to names is disrupted. These different disorders can be conceived as specific deficits at different processing stages in cognitive models, and suggests that these functional stages may have distinct neuroanatomic substrates. It remains to be seen whether a similar anatomic and functional variability is present in developmental prosopagnosia.

PMID:
24389150
DOI:
10.2741/e699
[Indexed for MEDLINE]

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