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Trends Endocrinol Metab. 2014 Apr;25(4):168-77. doi: 10.1016/j.tem.2013.12.004. Epub 2014 Jan 2.

Brown fat fuel utilization and thermogenesis.

Author information

1
Joslin Diabetes Center and Harvard Medical School, One Joslin Place, Boston, MA 02215, USA.
2
Joslin Diabetes Center and Harvard Medical School, One Joslin Place, Boston, MA 02215, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA. Electronic address: yu-hua.tseng@joslin.harvard.edu.

Abstract

Brown adipose tissue (BAT) dissipates energy as heat to maintain optimal thermogenesis and to contribute to energy expenditure in rodents and possibly humans. The energetic processes executed by BAT require a readily-available fuel supply, which includes glucose and fatty acids (FAs). FAs become available by cellular uptake, de novo lipogenesis, and multilocular lipid droplets in brown adipocytes. BAT also possesses a great capacity for glucose uptake and metabolism, and an ability to regulate insulin sensitivity. These properties make BAT an appealing target for the treatment of obesity, diabetes, and other metabolic disorders. Recent research has provided a better understanding of the processes of fuel utilization carried out by brown adipocytes, which is the focus of the current review.

KEYWORDS:

brown adipose tissue; energy expenditure; uncoupling protein 1

PMID:
24389130
PMCID:
PMC3972344
DOI:
10.1016/j.tem.2013.12.004
[Indexed for MEDLINE]
Free PMC Article

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