Format

Send to

Choose Destination
See comment in PubMed Commons below
Brain Res. 2014 Oct 10;1584:22-7. doi: 10.1016/j.brainres.2013.12.033. Epub 2014 Jan 2.

Tau mRNA is present in axonal RNA granules and is associated with elongation factor 1A.

Author information

1
Department of Clinical Neuroscience, Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, United Kingdom.
2
Department of Clinical Neuroscience, Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, United Kingdom. Electronic address: jean-marc.gallo@kcl.ac.uk.

Abstract

The microtubule-associated protein tau is predominantly localized in the axonal compartment over the entire length of the axon in neurons. The mechanisms responsible for the localization of tau in axons at long distance from the cell body are not properly understood. Using fluorescence in situ hybridization, we show that tau mRNA is present in the central and distal parts of the axons of cultured rat cortical neurons. Axonal tau mRNA is associated with granules which are distributed throughout the entire length of the axon, including the growth cone. We also show that tau mRNA-containing axonal particles are associated with elongation factor 1A, a component of the protein translation machinery. The presence of tau mRNA in axons might be at least part of the process by which tau is localized to distal axons.

KEYWORDS:

Axon; Tau; eEF1A; mRNA

PMID:
24389033
DOI:
10.1016/j.brainres.2013.12.033
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center