Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Biol. 2014 Jan 20;24(2):117-23. doi: 10.1016/j.cub.2013.11.039. Epub 2014 Jan 2.

A novel analgesic isolated from a traditional Chinese medicine.

Author information

1
Department of Pharmacology, University of California, Irvine, Irvine, CA 92697, USA.
2
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
3
School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
4
Department of Anesthesiology and Perioperative Care, University of California, Irvine, CA 92697, USA.
5
Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697, USA.
6
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. Electronic address: liangxm@dicp.ac.cn.
7
Department of Pharmacology, University of California, Irvine, Irvine, CA 92697, USA; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92697, USA; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: ocivelli@uci.edu.

Abstract

BACKGROUND:

Current pain management is limited, in particular, with regard to chronic pain. In an attempt to discover novel analgesics, we combined the approach developed to characterize traditional Chinese medicine (TCM), as part of the "herbalome" project, with the reverse pharmacology approach aimed at discovering new endogenous transmitters and hormones.

RESULTS:

In a plant used for centuries for its analgesic properties, we identify a compound, dehydrocorybulbine (DHCB), that is effective at alleviating thermally induced acute pain. We synthesize DHCB and show that it displays moderate dopamine receptor antagonist activities. By using selective pharmacological compounds and dopamine receptor knockout (KO) mice, we show that DHCB antinociceptive effect is primarily due to its interaction with D2 receptors, at least at low doses. We further show that DHCB is effective against inflammatory pain and injury-induced neuropathic pain and furthermore causes no antinociceptive tolerance.

CONCLUSIONS:

Our study casts DHCB as a different type of analgesic compound and as a promising lead in pain management.

PMID:
24388848
PMCID:
PMC3912990
DOI:
10.1016/j.cub.2013.11.039
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center