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Cytokine. 2014 Feb;65(2):134-7. doi: 10.1016/j.cyto.2013.12.004. Epub 2013 Dec 31.

Vitamin D sufficiency associates with an increase in anti-inflammatory cytokines after intense exercise in humans.

Author information

1
The Orthopedic Specialty Hospital, Murray, UT 84107, USA. Electronic address: tyler.barker@imail.org.
2
ARUP Laboratories, Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA.
3
ARUP Laboratories, Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA; Department of Pathology, University of Utah, Salt Lake City, UT 84132, USA.
4
USANA Health Sciences, Inc., Salt Lake City, UT 84120, USA.
5
The Orthopedic Specialty Hospital, Murray, UT 84107, USA.
6
Hyperbaric Medicine, Intermountain Medical Center, Murray, UT 84107, USA; Hyperbaric Medicine, LDS Hospital, Salt Lake City, UT 84143, USA; University of Utah, School of Medicine, Salt Lake City, UT 84132, USA.

Abstract

The purpose of this study was to identify the influence of vitamin D status (insufficient vs. sufficient) on circulating cytokines and skeletal muscle strength after muscular injury. To induce muscular injury, one randomly selected leg (SSC) performed exercise consisting of repetitive eccentric-concentric contractions. The other leg served as the control. An averaged serum 25(OH)D concentration from two blood samples collected before exercise and on separate occasions was used to establish vitamin D insufficiency (<30ng/mL, n=6) and sufficiency (>30ng/mL, n=7) in young, adult males. Serum cytokine concentrations, single-leg peak isometric force, and single-leg peak power output were measured before and during the days following the exercise protocol. The serum IL-10 and IL-13 responses to muscular injury were significantly (both p<0.05) increased in the vitamin D sufficient group. The immediate and persistent (days) peak isometric force (p<0.05) and peak power output (p<0.05) deficits in the SSC leg after the exercise protocol were not ameliorated with vitamin D sufficiency. We conclude that vitamin D sufficiency increases the anti-inflammatory cytokine response to muscular injury.

KEYWORDS:

Cytokines; Skeletal muscle strength; Vitamin D

PMID:
24388225
DOI:
10.1016/j.cyto.2013.12.004
[Indexed for MEDLINE]

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