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Cell Stem Cell. 2014 Jan 2;14(1):1-2. doi: 10.1016/j.stem.2013.12.002.

HSPCs get their motors running for asymmetric fate choice.

Author information

1
Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. Electronic address: yi.zheng@cchmc.org.
2
Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA; Institute for Molecular Medicine, University of Ulm, Ulm 89081, Germany.

Abstract

Contractile forces are implicated in cell polarity and asymmetric division, but their contribution to cell fate is unclear. In this issue of Cell Stem Cell, Shin et al. (2014) show that myosin-II isoforms sense matrix stiffness in hematopoietic stem and progenitor cells, with polarized myosin-IIB promoting asymmetric self-renewal and constitutive myosin-IIA activation promoting cytokine-triggered differentiation.

PMID:
24388168
PMCID:
PMC3916825
DOI:
10.1016/j.stem.2013.12.002
[Indexed for MEDLINE]
Free PMC Article

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