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Leuk Res. 2014 Mar;38(3):269-74. doi: 10.1016/j.leukres.2013.12.008. Epub 2013 Dec 15.

Magnetic fields exposure and childhood leukemia risk: a meta-analysis based on 11,699 cases and 13,194 controls.

Author information

  • 1Epidemiology and Statistics, School of Public Health, Jilin University, Changchun, Jilin, China.
  • 2Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, Jilin University, Changchun, China.
  • 3School of Mathematics and Statistics, Northeast Normal University, Changchun, Jilin, China.
  • 4Epidemiology and Statistics, School of Public Health, Jilin University, Changchun, Jilin, China. Electronic address: xliu@jlu.edu.cn.

Abstract

OBJECTIVE:

To observe the association between childhood leukemia and magnetic field exposure.

METHODS:

The literature was searched by PubMed, ProQuest, Web of Science (SCI) and Medline databases during 1997-2013. Heterogeneity in several studies was weighted by I-squared value. Publication bias was tested by funnel plot and Egger's test. Odds ratio (OR) and 95% CI were used to evaluate the association strength. The statistical analyses in present study were carried out by STATA software package (version 12.0, College Station, TX).

RESULTS:

A total of 11,699 cases and 13,194 controls in 9 studies were stratified by different exposure cut-off points. On condition of the reference <0.1 μT, statistical association between magnetic field intensity ≥0.4 μT and childhood leukemia was exhibited (for total leukemia: OR = 1.57, 95% CI = 1.03-2.40; for acute lymphocytic leukemia: OR=2.43, 95% CI = 1.30-4.55). On condition of the reference level of <0.2 μT, the positive association between magnetic field intensity ≥0.2 μT and childhood leukemia was found (OR = 1.31, 95% CI = 1.06-1.61).

CONCLUSIONS:

The result in this meta-analysis indicated that magnetic field exposure level may be associated with childhood leukemia.

KEYWORDS:

Childhood; Leukemia; Magnetic field; Meta-analysis; Risk

PMID:
24388073
DOI:
10.1016/j.leukres.2013.12.008
[PubMed - indexed for MEDLINE]
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