Format

Send to

Choose Destination
See comment in PubMed Commons below
J Crohns Colitis. 2014 Jul;8(7):654-61. doi: 10.1016/j.crohns.2013.12.005. Epub 2013 Dec 30.

Phenotypic concordance in familial inflammatory bowel disease (IBD). Results of a nationwide IBD Spanish database.

Author information

1
Hospital Universitari Germans Trias i Pujol, Badalona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain. Electronic address: ecabre.germanstrias@gencat.cat.
2
Hospital Universitari Germans Trias i Pujol, Badalona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.
3
Hospital Universitario Reina Sofía, Córdoba, Spain.
4
Hospital General Universitario, Alicante, Spain.
5
Hospital Clínic, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.
6
Hospital Universitari Mútua de Terrassa, Terrassa, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.
7
Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.
8
Hospital Universitari La Fe, Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.
9
Hospital de Cruces, Barakaldo, Spain.
10
Hospital Universitario Infanta Leonor, Madrid, Spain.
11
Hospital Universitario de La Princesa, IP, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.
12
Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
13
Hospital Royo Villanova, Zaragoza, Spain.
14
Hospital Galdakao-Usansolo, Galdakao, Spain.
15
Hospital General San Jorge, Huesca, Spain.

Abstract

BACKGROUND & AIMS:

Disease outcome has been found to be poorer in familial inflammatory bowel disease (IBD) than in sporadic forms, but assessment of phenotypic concordance in familial IBD provided controversial results. We assessed the concordance for disease type and phenotypic features in IBD families.

METHODS:

Patients with familial IBD were identified from the IBD Spanish database ENEIDA. Families in whom at least two members were in the database were selected for concordance analysis (κ index). Concordance for type of IBD [Crohn's disease (CD) vs. ulcerative colitis (UC)], as well as for disease extent, localization and behaviour, perianal disease, extraintestinal manifestations, and indicators of severe disease (i.e., need for immunosuppressors, biological agents, and surgery) for those pairs concordant for IBD type, were analyzed.

RESULTS:

798 out of 11,905 IBD patients (7%) in ENEIDA had familial history of IBD. Complete data of 107 families (231 patients and 144 consanguineous pairs) were available for concordance analyses. The youngest members of the pairs were diagnosed with IBD at a significantly younger age (p<0.001) than the oldest ones. Seventy-six percent of pairs matched up for the IBD type (κ=0.58; 95%CI: 0.42-0.73, moderate concordance). There was no relevant concordance for any of the phenotypic items assessed in both diseases.

CONCLUSIONS:

Familial IBD is associated with diagnostic anticipation in younger individuals. Familial history does not allow predicting any phenotypic feature other than IBD type.

KEYWORDS:

Concordance analysis; Crohn's disease; Familial aggregation; Inflammatory bowel disease; Ulcerative colitis

PMID:
24388046
DOI:
10.1016/j.crohns.2013.12.005
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center