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Trends Microbiol. 2014 Feb;22(2):57-8. doi: 10.1016/j.tim.2013.12.009. Epub 2013 Dec 31.

HCV-like IRESs sequester eIF3: advantage virus.

Author information

1
Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
2
Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India. Electronic address: sdas@mcbl.iisc.ernet.in.

Abstract

In a recent Nature paper, Hashem et al. attempted to probe deeper into the elusive role of eIF3 in translation initiation of viruses with hepatitis C virus-like internal ribosome entry sites (IRESs), but instead uncovered a surprising role of these IRESs in displacing eIF3 from the 40S subunit, favoring viral translation.

PMID:
24387882
DOI:
10.1016/j.tim.2013.12.009
[Indexed for MEDLINE]
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