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Int J Stem Cells. 2013 Nov;6(2):75-86.

Specific protein markers for stem cell cross-talk with neighboring cells in the environment.

Author information

1
Department of Chemical and Biomolecular Engineering and Sogang University, Seoul, Korea.
2
School of Chemical Engineering and Sungkyunkwan University, Suwon.
3
Department of Chemical and Biomolecular Engineering and Sogang University, Seoul, Korea ; Graduate School of Management of Technology, Sogang University, Seoul, Korea.
4
School of Chemical Engineering and Sungkyunkwan University, Suwon ; SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University, Suwon.

Abstract

A stem cell interacts with the neighboring cells in its environment. To maintain a living organism's metabolism, either cell-cell or cell-environment interactions may be significant. Usually, these cells communicate with each other through biological signaling by interactive behaviors of primary proteins or complementary chemicals. The signaling intermediates offer the stem cell's functionality on its metabolism. With the rapid advent of omics technologies, various specific markers by which stem cells cooperate with their surroundings have been discovered and established. In this article, we review several stem cell markers used to communicate with either cancer or immune cells in the human body.

KEYWORDS:

Cancer cell; Immune cell; Protein marker; Signaling cross-talk; Stem cell

PMID:
24386551
PMCID:
PMC3878207

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