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Toxicol Res. 2013 Sep;29(3):157-64. doi: 10.5487/TR.2013.29.3.157.

Loss of Integrity: Impairment of the Blood-brain Barrier in Heavy Metal-associated Ischemic Stroke.

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College of Pharmacy, Hanyang University, Gyeonggi-do, Korea.
Department of Biotechnology and Bioinformatics, Korea University, Sejong City, Korea.
College of Pharmacy, Hanyang University, Gyeonggi-do, Korea ; Institute of Pharmaceutical Science and Technology, Hanyang University, Gyeonggi-do, Korea.


Although stroke is one of the leading causes of death and disability worldwide, preventive or therapeutic options are still limited. Therefore, a better understanding of the pathophysiological characteristics of this life-threatening disease is urgently needed. The incidence and prevalence of ischemic stroke are increased by exposure to certain types of xenobiotics, including heavy metals, suggesting the possible toxicological contribution of these compounds to the onset or aggravation of stroke. Among the potential targets, we have focused on alterations to cerebral endothelial cells (CECs), which play important roles in maintaining the functional integrity of brain tissue.


Blood-brain barrier; Heavy metals; Ischemic stroke; Neurovascular unit; Tight junction

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