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Turk J Haematol. 2013 Mar;30(1):58-62. doi: 10.4274/tjh.2011.0047. Epub 2013 Mar 5.

Central nervous system involvement of epstein barr virus associated lymphoproliferative disorder in a child with acute lymphoblastic leukemia: successful treatment with rituximab and interferon-alpha.

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Tepecik Training and Research Hospital, Department of Pediatrics Clinic, İzmir, Turkey.


in English, Turkish

Central nervous system (CNS) involvement of Epstein-Barr virus (EBV)-associated lymphoproliferative disease is a rare and serious complication in children with leukemia. Although rituximab therapy seems to be promising in these cases, persistent hypogammaglobulinemia may appear after treatment due to complete depletion of normal B lymphocytes in the peripheral blood. Here we report isolated CNS involvement of EBV-associated lymphoproliferative disorder in a 4-year-old boy with acute leukemia. The patient was treated with rituximab and interferon alpha; however, persistent hypogammaglobulinemia developed as a complication. Given the rarity of the complication in children receiving these agents, our experience with such a case may be helpful to others.


None declared.


Epstein-Barr virus; Leukemia; Lymphoproliferative disorder; Rituximab; children

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