Format

Send to

Choose Destination
J Cell Biol. 2013 Nov 25;203(4):563-74. doi: 10.1083/jcb.201306041.

Where is mTOR and what is it doing there?

Author information

1
Biozentrum, University of Basel, CH-4056 Basel, Switzerland.

Abstract

Target of rapamycin (TOR) forms two conserved, structurally distinct kinase complexes termed TOR complex 1 (TORC1) and TORC2. Each complex phosphorylates a different set of substrates to regulate cell growth. In mammals, mTOR is stimulated by nutrients and growth factors and inhibited by stress to ensure that cells grow only during favorable conditions. Studies in different organisms have reported localization of TOR to several distinct subcellular compartments. Notably, the finding that mTORC1 is localized to the lysosome has significantly enhanced our understanding of mTORC1 regulation. Subcellular localization may be a general principle used by TOR to enact precise spatial and temporal control of cell growth.

PMID:
24385483
PMCID:
PMC3840941
DOI:
10.1083/jcb.201306041
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center