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J Neuroimmune Pharmacol. 2014 Jun;9(3):285-92. doi: 10.1007/s11481-013-9519-8. Epub 2014 Jan 3.

Sorting through the roles of beclin 1 in microglia and neurodegeneration.

Author information

1
Cell and Molecular Biology Program, Stanford University, Stanford, CA, 94305, USA.

Abstract

Beclin 1 has a well-established role in regulating autophagy, a cellular degradation pathway. Although the yeast ortholog of beclin 1 (Atg6/Vps30) was discovered to also regulate vacuolar protein sorting nearly 30 years ago, the varied functions of beclin 1 in mammalian cells are only beginning to be sorted out. We recently described a role for beclin 1 in regulating recycling of phagocytic receptors in microglia, a function analogous to that of its yeast ortholog. Microglia lacking beclin 1 have a reduced phagocytic capacity, which impairs clearance of amyloid β (Aβ) in a mouse model of Alzheimer's Disease (AD). Here we summarize these findings and discuss the implications for beclin 1-regulated receptor recycling in neurodegenerative disease.

PMID:
24385262
PMCID:
PMC4019692
DOI:
10.1007/s11481-013-9519-8
[Indexed for MEDLINE]
Free PMC Article

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