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Hum Genet. 2014 Apr;133(4):459-61. doi: 10.1007/s00439-013-1412-2. Epub 2014 Jan 3.

SLC6A4 polymorphism, population genetics, and psychiatric traits.

Author information

1
Department of Psychiatry, Genetics and Neurobiology, Yale University School of Medicine and VA CT Healthcare Center, New Haven, CT, USA, joel.gelernter@yale.edu.

Abstract

5HTTLPR, which is the trivial name for a variable number of tandem repeats (VNTR) polymorphism mapped to the 5' region of the SLC6A4 (serotonin transporter protein) gene, is one of the most studied variants with respect to psychiatric traits. It is also widely studied in the context of intermediate phenotypes such as neuroimaging measures, and gene-by-environment interaction, the latter generally in the context of affective and anxiety phenotypes. In this article, the author discusses the importance of the variant in the context of a population genetics article published in Human Genetics sixteen years ago.

PMID:
24385047
PMCID:
PMC3992709
DOI:
10.1007/s00439-013-1412-2
[Indexed for MEDLINE]
Free PMC Article

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