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Nat Rev Microbiol. 2014 Feb;12(2):101-14. doi: 10.1038/nrmicro3160. Epub 2014 Jan 2.

Bacteria-autophagy interplay: a battle for survival.

Author information

1
Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G1X8, Canada.
2
1] Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G1X8, Canada. [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S1A8, Canada. [3] Institute of Medical Science, University of Toronto, Toronto, Ontario M5S1A8, Canada.

Abstract

Autophagy is a cellular process that targets proteins, lipids and organelles to lysosomes for degradation, but it has also been shown to combat infection with various pathogenic bacteria. In turn, bacteria have developed diverse strategies to avoid autophagy by interfering with autophagy signalling or the autophagy machinery and, in some cases, they even exploit autophagy for their growth. In this Review, we discuss canonical and non-canonical autophagy pathways and our current knowledge of antibacterial autophagy, with a focus on the interplay between bacterial factors and autophagy components.

PMID:
24384599
DOI:
10.1038/nrmicro3160
[Indexed for MEDLINE]

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