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Eur J Pharmacol. 2014 Feb 5;724:132-9. doi: 10.1016/j.ejphar.2013.12.028. Epub 2013 Dec 30.

Neuroprotective and antioxidant effects of curcumin in a ketamine-induced model of mania in rats.

Author information

1
Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Pelotas, Rio Grande do Sul, Brazil.
2
Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.
3
Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Pelotas, Rio Grande do Sul, Brazil. Electronic address: ghisleni.g@gmail.com.

Abstract

Bipolar disorder (BD) is a chronic and debilitating illness characterized by recurrent manic and depressive episodes. Our research investigates the protective effects of curcumin, the main curcuminoid of the Indian spice turmeric, in a model of mania induced by ketamine administration in rats. Our results indicated that ketamine treatment (25 mg/kg, for 8 days) induced hyperlocomotion in the open-field test and oxidative damage in prefrontal cortex (PFC) and hippocampus (HP), evaluated by increased lipid peroxidation and decreased total thiol content. Moreover, ketamine treatment reduced the activity of the antioxidant enzymes superoxide dismutase and catalase in the HP. Pretreatment of rats with curcumin (20 and 50 mg/kg, for 14 days) or with lithium chloride (45 mg/kg, positive control) prevented behavioral and pro-oxidant effects induced by ketamine. These findings suggest that curcumin might be a good compound for preventive intervention in BD, reducing the episode relapse and the oxidative damage associated with the manic phase of this disorder.

KEYWORDS:

Antioxidant; Curcumin; Ketamine; Mania; Neuroprotective

PMID:
24384407
DOI:
10.1016/j.ejphar.2013.12.028
[Indexed for MEDLINE]

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