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Chem Commun (Camb). 2014 Feb 14;50(13):1561-3. doi: 10.1039/c3cc48853e.

Quencher-free molecular beacons as probes for oligonucleotides containing CAG repeat sequences.

Author information

1
Department of Chemistry, BK School of Molecular Science, Pohang University of Science and Technology, Pohang 790-784, South Korea. bhkim@postech.ac.kr.

Abstract

We have identified quencher-free molecular beacons that allow the sensitive probing of CAG repeat oligonucleotides, including mRNA fragments of trinucleotide repeat diseases, with significant increases in fluorescence intensity mediated by disruption of the stacking of their (Py)U units.

PMID:
24382518
DOI:
10.1039/c3cc48853e
[Indexed for MEDLINE]

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