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J Biol Regul Homeost Agents. 2013 Oct-Dec;27(4):955-9.

Luteolin inhibits mast cell-mediated allergic inflammation.

Author information

1
Department of Microbiology and Infectious Diseases, School of Veterinary Medicine, Aristotle University of Thessaloniki, Macedonia, Greece.
2
Department of Dermatology, University of Rome Tor Vergata, Rome, Italy.
3
Dental School, University of Chieti-Pescara, Italy.
4
Orthopedic Division, University of Perugia, Perugia, Italy.
5
Immunology Division, Medical School, University of Chieti-Pescara, Chieti, Italy.
6
Orthopedic Division, University of Chieti-Pescara, Chieti, Italy.
7
Department of Neurosciences and Imaging, Faculty of Medicine and Surgery, G. d'’Annunzio University Chieti-Pescara, Chieti, Italy.
8
Department of Parasitology, School of Veterinary Medicine, University of Thessaloniki, Macedonia, Greece.
9
Gynecology Clinic, Pescara Hospital, Pescara, Italy.
10
Nicola’s Foundation, Onlus, Arezzo, Italy.
11
Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy.
12
Department of Pharmacology and Experimental Therapeutics, Biochemistry and Internal Medicine Tufts University School of Medicine, Tufts-New England Medi-cal Center, Boston, MA, USA.

Abstract

Mast cells are ubiquitous in the body and multifunctional immune cells; they are known to be primary responders in allergic reactions, orchestrating strong responses to minute amounts of allergens. Mature mast cells perform important beneficial roles in host defense, both in IgE-dependent immune responses to certain parasites and in natural immunity to bacterial infection. In IgE-associated biological responses, the crosslinking of FcεRI-bound IgE with multivalent antigens initiate the activation of mast cells by promoting aggregation of FceRI. This cross-linking receptor-bound IgE by multivalent Ag initiates a cascade of intracellular reactions leading to mediator release such as proinflammatory mediators, chemokines and cytokines. Luteolin belongs to a flavone group of compounds called flavonoids, it has anti-oxidant properties, inhibits some cancer cell proliferation and exerts a regulatory effect on mast cell-mediated inflammatory diseases and allergy. Here we report the impact of luteolin on mast cell activation.

PMID:
24382176
[Indexed for MEDLINE]
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