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Biomed Res Int. 2013;2013:519126. doi: 10.1155/2013/519126. Epub 2013 Dec 4.

The effect of conditioned media of adipose-derived stem cells on wound healing after ablative fractional carbon dioxide laser resurfacing.

Author information

1
Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
2
Nanjing Regenerative Medicine Engineering and Technology Research Center, Nanjing 210029, China.

Abstract

OBJECTIVE:

To evaluate the benefits of conditioned medium of Adipose-derived stem cells (ADSC-CM) on wound healing after fractional carbon dioxide laser resurfacing (FxCR) on human skin.

MATERIALS AND METHODS:

Nineteen subjects were treated with FxCR on the bilateral inner arms. ADSC-CM was applied on FxCR site of one randomly selected arm. Transepidermal water loss (TEWL), skin color, and gross-elasticity of FxCR site on both arms were measured. Skin samples were taken by biopsy from three subjects 3 weeks after treatment for histopathological manifestations and mRNA expressions of procollagen types I and III, elastin genes were noted.

RESULTS:

The index of erythema, melanin, and TEWL of the ADSC-CM-treated skin were significantly lower than those of the control side. The mRNA expression of type III procollagen in ADSC-CM-treated group at 3 weeks posttreatment was 2.6 times of that of the control group.

CONCLUSION:

Application of allograft ADSC-CM is an effective method for enhancing wound healing after FxCR, by reducing transient adverse effects such as erythema, hyperpigmentation, and increased TEWL.

PMID:
24381938
PMCID:
PMC3867954
DOI:
10.1155/2013/519126
[Indexed for MEDLINE]
Free PMC Article

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