Recent Advances in Mass Spectrometry for the Identification of Neuro-chemicals and their Metabolites in Biofluids

Suresh Kumar Kailasa; Hui-Fen Wu

doi:10.2174/1570159X11311040007

Recent Advances in Mass Spectrometry for the Identification of Neuro-chemicals and their Metabolites in Biofluids

Curr Neuropharmacol. 2013 Jul;11(4):436-64. doi: 10.2174/1570159X11311040007.

Authors

Suresh Kumar Kailasa¹, Hui-Fen Wu²

Affiliations

¹ Department of Applied Chemistry, S. V. National Institute of Technology, Surat - 395007, India;
² Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, 80424, Taiwan; ; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, 800, Kaohsiung, Taiwan; ; Center for Nanoscience and Nanotechnology, National Sun Yat-Sen University, Kaohsiung, 80424, Taiwan; ; Doctoral Degree Program in Marine Biotechnology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.

Abstract

Recently, mass spectrometric related techniques have been widely applied for the identification and quantification of neurochemicals and their metabolites in biofluids. This article presents an overview of mass spectrometric techniques applied in the detection of neurological substances and their metabolites from biological samples. In addition, the advances of chromatographic methods (LC, GC and CE) coupled with mass spectrometric techniques for analysis of neurochemicals in pharmaceutical and biological samples are also discussed.

Keywords: CE-MS; GC-MS; LC-MS; MALDI-MS.; Neurochemicals.