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Cancer Invest. 2014 Jan;32(1):13-21. doi: 10.3109/07357907.2013.861472.

Axitinib affects cell viability and migration of a primary foetal lung adenocarcinoma culture.

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1Department of Thoracic Surgery, "G. Mazzini" Hospital, Faculty of Medicine and Surgery, University of L'Aquila , Teramo , Italy.


Fetal lung adenocarcinoma (FLAC) is a rare variant of lung adenocarcinoma. Studies regarding FLAC have been based only on histopathological observations, thus representative in vitro models of FLAC cultures are unavailable. We have established and characterized a human primary FLAC cell culture, exploring its biology, chemosensitivity, and migration. FLAC cells and specimen showed significant upregulation of VEGF165 and HIF-1α mRNA levels. This observation was confirmed by in vitro chemosensitivity and migration assay, showing that only Axitinib was comparable to Cisplatin treatment. We provide a suitable in vitro model to further investigate the nature of this rare type of cancer.

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