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World J Gastroenterol. 2013 Dec 14;19(46):8552-61. doi: 10.3748/wjg.v19.i46.8552.

Pathophysiology of cystic fibrosis and drugs used in associated digestive tract diseases.

Author information

1
Adriana Haack, Giselle Gonçalves Aragão, Maria Rita Carvalho Garbi Novaes, Department of Health, Universidade Paulista (UNIP), Brasília 70381701, Brazil.

Abstract

Cystic fibrosis (CF) causes chronic infections in the respiratory tract and alters the digestive tract. This paper reviews the most important aspects of drug treatment and changes in the digestive tract of patients with CF. This is a review of the literature, emphasizing the discoveries made within the last 15 years by analyzing scientific papers published in journals indexed in the Scientific Electronic Library Online, Sciences Information, United States National Library of Medicine and Medical Literature Analysis and Retrieval System Online databases, both in English and Portuguese, using the key words: cystic fibrosis, medication, therapeutic, absorption, digestion. Randomized, observational, experimental, and epidemiological clinical studies were selected, among others, with statistical significance of 5%. This review evaluates the changes found in the digestive tract of CF patients including pancreatic insufficiency, constipation and liver diseases. Changes in nutritional status are also described. Clinical treatment, nutritional supplementation and drug management were classified in this review as essential to the quality of life of CF patients, and became available through public policies for monitoring and treating CF. The information gathered on CF and a multi professional approach to the disease is essential in the treatment of these patients.

KEYWORDS:

Absorption; Cystic fibrosis; Digestion; Medication; Therapeutic

PMID:
24379572
PMCID:
PMC3870500
DOI:
10.3748/wjg.v19.i46.8552
[Indexed for MEDLINE]
Free PMC Article

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