Send to

Choose Destination
Nat Rev Immunol. 2014 Feb;14(2):69-80. doi: 10.1038/nri3570. Epub 2013 Dec 31.

Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling.

Author information

Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Illinois 60637, USA.
Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
1] Department of Discovery Immunology, Genentech Inc. [2] Division of Immunobiology and the Center for Systems Immunology, Cincinnati Children's Hospital Medical Center, Ohio 45229-3039, USA.


The development of B cells is dependent on the sequential DNA rearrangement of immunoglobulin loci that encode subunits of the B cell receptor. The pathway navigates a crucial checkpoint that ensures expression of a signalling-competent immunoglobulin heavy chain before commitment to rearrangement and expression of an immunoglobulin light chain. The checkpoint segregates proliferation of pre-B cells from immunoglobulin light chain recombination and their differentiation into B cells. Recent advances have revealed the molecular circuitry that controls two rival signalling systems, namely the interleukin-7 (IL-7) receptor and the pre-B cell receptor, to ensure that proliferation and immunoglobulin recombination are mutually exclusive, thereby maintaining genomic integrity during B cell development.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center