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Nat Rev Immunol. 2014 Feb;14(2):69-80. doi: 10.1038/nri3570. Epub 2013 Dec 31.

Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling.

Author information

1
Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Illinois 60637, USA.
2
Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
3
1] Department of Discovery Immunology, Genentech Inc. [2] Division of Immunobiology and the Center for Systems Immunology, Cincinnati Children's Hospital Medical Center, Ohio 45229-3039, USA.

Abstract

The development of B cells is dependent on the sequential DNA rearrangement of immunoglobulin loci that encode subunits of the B cell receptor. The pathway navigates a crucial checkpoint that ensures expression of a signalling-competent immunoglobulin heavy chain before commitment to rearrangement and expression of an immunoglobulin light chain. The checkpoint segregates proliferation of pre-B cells from immunoglobulin light chain recombination and their differentiation into B cells. Recent advances have revealed the molecular circuitry that controls two rival signalling systems, namely the interleukin-7 (IL-7) receptor and the pre-B cell receptor, to ensure that proliferation and immunoglobulin recombination are mutually exclusive, thereby maintaining genomic integrity during B cell development.

PMID:
24378843
PMCID:
PMC4276135
DOI:
10.1038/nri3570
[Indexed for MEDLINE]
Free PMC Article

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