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Prostaglandins Leukot Essent Fatty Acids. 2014 Feb-Mar;90(2-3):69-75. doi: 10.1016/j.plefa.2013.12.003. Epub 2013 Dec 18.

Treatment with omega-3 fatty acid ethyl-ester alters fatty acid composition of lipoproteins in overweight or obese adults with insulin resistance.

Author information

1
Department of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, United States.
2
Cardiovascular Health Research Center, Sanford Research, Sioux Falls, SD, United States; Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, United States; Department of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, United States.
3
Department of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, United States; Department of Medicine, University of Rochester Medical Center, United States. Electronic address: Robert_Block@urmc.rochester.edu.

Abstract

INTRODUCTION:

The effects of dietary fatty acid supplementation on lipoprotein fatty acid composition have rarely been described.

PATIENTS AND METHODS:

Sixty-one overweight and obese adults with dyslipidemia and insulin resistance were randomized to placebo, 2g/day extended-release nicotinic acid (ERN), 4g/day prescription omega-3 fatty acid ethyl ester (P-OM3), or combination therapy for 16 weeks. Lipoprotein fatty acid composition was analyzed by gas chromatography pre- and post-treatment.

RESULTS:

Treatment with P-OM3 or combination, but not ERN, increased proportions of eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid, and reduced those for arachidonic acid in all lipoprotein fractions, with greatest impact in the high-density lipoprotein fraction. P-OM3-induced changes in eicosapentaenoic acid within low-density lipoproteins and very low-density lipoproteins were associated with beneficial effects on mean arterial pressure and pulse pressure.

CONCLUSIONS:

P-OM3 supplementation, with or without ERN, was associated with differentially altered lipoprotein fatty acid composition and improved blood pressure parameters.

KEYWORDS:

AA; DHA; EPA; Fish oil; HDL; LA; LDL; Nicotinic acid; VLDL

PMID:
24378016
PMCID:
PMC3959884
DOI:
10.1016/j.plefa.2013.12.003
[Indexed for MEDLINE]
Free PMC Article
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