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PLoS One. 2013 Dec 23;8(12):e83827. doi: 10.1371/journal.pone.0083827. eCollection 2013.

Relationship between HbA1c and continuous glucose monitoring in Chinese population: a multicenter study.

Author information

  • 1Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, China.
  • 2Department of Endocrinology and Metabolism, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
  • 3Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.
  • 4Department of Endocrinology and Metabolism, China-Japan Friendship Hospital, Beijing, China.
  • 5Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  • 6Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated First People's Hospital, Shanghai, China.
  • 7Department of Endocrinology and Metabolism, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • 8Department of Endocrinology and Metabolism, Fudan University Affiliated Zhongshan Hospital, Shanghai, China.
  • 9Department of Endocrinology and Metabolism, The First People's Hospital of Foshan, Foshan, China.
  • 10Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • 11Department of Diabetic Neurology, Metabolic Disease Hospital, Tianjin Medical University, Tianjin, China.

Abstract

OBJECTIVE:

Since there is a paucity of reference data in the literature to indicate the relationship between HbA1c, and 24 h mean blood glucose (MBG) from continuous glucose monitoring (CGM) in Chinese populations, we described the above relationship in adult Chinese subjects with different glucose tolerance status.

METHODS:

Seven-hundred-and-forty-two individuals without history of diabetes were included to the study at 11 hospitals in urban areas across China from 2007-2009 and data of 673 subjects were included into the final analysis. Oral glucose tolerance test (OGTT) classified the participants as nondiabetic subjects, including those with normal glucose regulation (NGR; n = 121) and impaired glucose regulation (IGR; n = 209), or newly diagnosed type 2 diabetes (n = 343). All participants completed testing for HbA1c levels and wore a CGM system for three consecutive days. The 24 h MBG levels were calculated. Spearman correlations and linear regression analyses were applied to quantify the relationship between glucose markers.

RESULTS:

The levels of HbA1c and 24 h MBG significantly increased with presence of glucose intolerance (NGR<IGR<type 2 diabetes; both, P<0.001). Analysis of the total population indicated that HbA1c was strongly correlated with 24 h MBG (r = 0.735). The correlation was also found to be significant for the subgroup of participants with newly diagnosed type 2 diabetes (r = 0.694, P<0.001). Linear regression analysis of the total study population yielded the following equation: 24 h MBG(mmol/L )= 1.198×HbA1c-0.582 (24 h MBG(mg/dL )= 21.564×HbA1c-10.476) (R(2)= 0.670, P<0.001). The model fit was not improved by application of exponential or quadratic modeling. When HbA1c was 6.5%, the calculated 24 h MBG was 7.2 (6.4-8.1) mmol/L (130 (115-146) mg/dL); and when HbA1c was 7.0%, the 24 h MBG was 7.8 (6.9-8.7) mmol/L (140 (124-157) mg/dL).

CONCLUSIONS:

Our study provided the reference data of the relationship between HbA1c and CGM in Chinese subjects.

PMID:
24376762
PMCID:
PMC3871656
DOI:
10.1371/journal.pone.0083827
[PubMed - indexed for MEDLINE]
Free PMC Article
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